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Welcome to the Hammarlund Lab

Regenerating GABA neurons in vivo following laser surgery
Regenerating GABA neurons in vivo following laser surgery


We study the genetics and cell biology of axon regeneration and degeneration using the model organism C. elegans.

Axon plasticity in the nervous system can result from experience, injury, or disease. Changes in axon structure can profoundly affect the connectivity and function of the nervous system. How is axon plasticity regulated and executed?

We have developed a suite of genetic tools to initiate and monitor regeneration and degeneration, two fundamental forms of axon plasticity. We have used these tools to identify genes required for regeneration and degeneration. We also use laser surgery to sever individual axons. Because C. elegans is transparent and has a simple nervous system, we can observe regeneration and degeneration in vivo. Our long-term goal is to understand and control plasticity at the molecular level.



News

2009

October 6: Welcome postdoc Alexandra Byrne

June 24-28: International C. elegans Meeting

June 10: "Imaging Axon Regeneration in vivo", Yale Microscopy Workshop

May 18: Welcome back grad student Tyson Edwards

May 7: Welcome back grad student Christopher Firnhaber

April 24: Arnold and Mabel Beckman Foundation Young Investigator Award.

Jan. 22: "Axon regeneration requires a conserved MAP kinase pathway" published in Science. PDF

Jan. 12: Welcome technician Laura Klein

Jan. 7: Welcome rotation student Tyson Edwards

Jan. 5: Welcome rotation student Christopher Firnhaber

2008

Dec. 12: Genetics Department Holiday Party

Dec. 12: Last day of Patrick McMillen's rotation.

Dec. 11: CNNR Open House



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